This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Arnold Brenner, MD; Raul A. Wapnir, PhD

Am J Dis Child. 1978;132(8):773-776.

Abstract
• A 3-year-old girl had behavioral deterioration, with hyperkinesis, irritability, and sleeping difficulties after the therapeutic administration of isoniazid. The administration of pharmacologic doses of pyridoxine hydrochloride led to a disappearance of symptoms. After discontinuing isoniazid therapy a similar pattern of behavior was noted that was controlled by pyridoxine. A placebo had no effect, but niacinamide was as effective as pyridoxine. Periodic withdrawal of pyridoxine was associated with return of the hyperkinesis. The level of pyridoxal in the blood was normal during the periods of relapse. Metabolic studies suggested a block in the kynurenine pathway of tryptophan metabolism. The patient has been followed for six years and has required pharmacologic doses of pyridoxine to control her behavior.

(Am J Dis Child 132:773-776, 1978)

Author Affiliations
From the Department of Pediatrics, University of Maryland School of Medicine, Baltimore. Dr Brenner is in private practice; Dr Wapnir is now with the North Shore University Hospital, Manhasset, NY.

Footnotes
Reprint requests to 8630 Liberty Plaza Mall, Randallstown, MD 21133 (Dr Brenner).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute Isoniazid Poisoning in Childhood
Miller et al.
Arch Pediatr Adolesc Med 1980;134:290-292.
ABSTRACT