Modification of recurrent otitis media by short-term sulfonamide therapy
C. W. Biedel
Alternating cases of upper respiratory infection (URI) occurring within two
months of an episode of otitis media were treated with either sulfonamides
or decongestants. One hundred three cases of uncomplicated URI were treated
with sulfonamide and 98 with decongestant. When adjusted for possible
recrudescence rather than recurrence the rate was 4/71 (5.6%) and 15/76
(20%) in the treated and control groups, respectively. This difference is
significant (P less than .001) and suggests that intermittent prophylactic
treatment can modify the recurrence rate of otitis media in children.
