The Coffin-Siris syndrome
W. W. Tunnessen Jr, J. A. McMillan and M. B. Levin
We present the sixth reported case of the Coffin-Siris syndrome. This
disorder is characterized by the absence of the nails of the fifth fingers
and toes, severe mental and developmental retardation, and postnatal growth
deficiency. Feeding and respiratory problems are prominent features. The
Dandy-Walker malformation was found at autopsy in our patient. This
malformation was also present in the only other patient with this syndrome
whose autopsy has been reported.
