Retinoblastoma and subband deletion of chromosome 13
J. J. Yunis and N. Ramsay
Two patients with retinoblastoma and an interstitial deletion of the long
arm of chromosome 13 were studied using G-banded metaphase and prophase
chromosomes. One patient showed several congenital defects, developmental
retardation, and deletion of bands q14 and q21. The second patient showed
mild developmental delay, a few minor congenital defects, and a loss of
approximately half of band q14. On the basis of this study and nine others
from the literature, it is now possible to tentatively assign a
predisposition to retinoblastoma to deletion of a specific small region of
chromosome 13.
