Takayasu's arteritis associated with glomerulonephritis. A case report
G. E. Zilleruelo, P. Ferrer, O. L. Garcia, M. Moore, V. Pardo and J. Strauss
Takayasu's disease is a nonspecific arteritis of unknown cause with
predilection for the aortic arch and its branches; approximately 20% of
those affected are children or adolescents, predominantly females. The
purpose of this article is to report the case of a young girl in which the
mode of presentation was microscopic hematuria and proteinuria.
Subsequently, aortic valvular insufficiency developed and there was
evidence of aortitis in the thoracic and abdominal aorta, as well as in the
arch. All functional and anatomical cardiac derangements were documented by
ultrasound and angiocardiography. Renal biopsies showed progressive
glomerular involvement characterized by focal and segmental
glomerulonephritis. It is postulated that a common immunologic mechanism
was responsible for the aortic and glomerular lesions.
