Premature coronary atherosclerosis in a 5-year-old with corticosteroid-refractory nephrotic syndrome
R. J. Kallen, R. K. Brynes, A. J. Aronson, C. Lichtig and B. H. Spargo
We report the case of a 5-year-old girl who died two years after onset of
the idiopathic nephrotic syndrome, which failed to respond to treatment
with corticosteroid and cyclophosphamide. Severe atherosclerotic changes
were noted in both coronary arteries. Prolonged hyperlipidemia in patients
with long-standing nephrotic syndrome may represent a major risk factor
predisposing to premature coronary atherosclerosis in children who are also
destined to develop chronic renal failure.
