You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 131 No. 8, August 1977 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Kentucky Appalachian goiter without iodine deficiency. Evidence for evanescent thyroiditis

D. R. Hollingsworth, L. K. Butcher and S. D. White

In Breathitt County, Kentucky, an Appalachian Mountain community, 1,267 children were examined to determine goiter prevalence. Matched pairs of 82 goitrous and nongoitrous children were reexamined six months later for family history, urinary iodine excretion, serum thyroxine, triiodothyronine, protein-bound iodine, thyrotropin, and thyroid autoantibodies. Goiter prevalence was 8.4%. Iodine deficiency was not found. Thyroid stimulating hormone levels were higher in the goitrous group. Microsomal autoantibody titers were elevated in 20% of the children with goiters vs 6% of controls (P less than .05). Fluorescent antibodies were associated with positive microsomal (P less than .01) but not with positive tanned RBC autoantibodies. Unexpectedly, on repeat examination, goiter was absent in 17 (21%) of the originally goitrous group, but was now present in 22 (25%) of the controls. We concluded that while evolving thyroiditis is common in Appalachian children, it does not explain all goiters in an area of abundant iodine intake and known familial goiter.





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1977 American Medical Association. All Rights Reserved.