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Gary D. Overturf, MD; Darleen Powars, MD; Larry J. Baraff, MD

Am J Dis Child. 1977;131(7):784-787.

Abstract
• A total of 422 patients with sickle cell disorders have been observed for 3,442 patient years. During this period, 53 episodes of septicemia or meningitis occurred, indicating a risk of 12.5% from these infections for each individual. If only patients with SS hemoglobinopathy (sickle cell anemia) (323 patients) are considered, the risk was 15.2%. The case fatality ratios for sepsis and meningitis were 35% and 10%, respectively.

Disease due to Streptococcus pneumoniae occurred, almost exclusively, among children with SS hemoglobinopathy who were less than 5 years of age. After the first decade, illnesses among patients with all types of sickle cell disorders were frequently associated with an identifiable source of infection, a chronic course, and frequent involvement of Gram-negative organisms.

(Am J Dis Child 131:784-787, 1977)

Author Affiliations
From the Department of Pediatrics, the Hastings Infectious Disease Laboratory, and the Sickle Cell Center of the University of Southern California and the Los Angeles County-University of Southern California Medical Center, Los Angeles.

Footnotes
Reprint requests to Hastings Infectious Disease Laboratory, 1129 N State St, Room 2-G-24, Los Angeles, CA 90033 (Dr Overturf).

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