Clinical manifestations of renal allograft derived primary cytomegalovirus infection
R. F. Betts, R. B. Freeman, R. G. Douglas Jr and T. E. Talley
Seventy seven patients, thirteen younger than 20 years of age, were
followed up prospectively for the first three months after renal transplant
for evidence of infection and illness due to cytomegalovirus (CMV).
Thirty-two developed reactivation of latent CMV and 29 did not develop any
CMV infection and wn, five had pneumonia, and four underwent nephrectomy.
Of these, 16, eleven received a kidney from a parent, whereas of the other
61 patients, five received parental kidneys (P less than .001). Hence, CMV
seronegative individuals who received a kidney from a CMV seropositive
parent developed clinical illness and sometimes lost the allograft.
