This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Reba M. Hill, MD; Willie M. Verniaud, EdD; Naoma F. Morgan, RN; Jeang Nowlin; Linda J. Glazener; Marjorie G. Horning, PhD

Am J Dis Child. 1977;131(5):546-550.

Abstract
• Utilizing methods of gas chromatography-mass spectrometry-computer systems operated in a chemical ionization mode, metabolites of mephobarbital were demonstrated in urines collected from two infants whose mother was treated with mephobarbital during pregnancy. Identification of the major metabolite in one infant was possible for 22 days after delivery. The urinary half-life of mephobarbital was 30 hours and the half-life of phenobarbital was 48 hours. Both infants demonstrated withdrawal symptoms for four to six months and manifested the physical phenotype of infants exposed in utero to anticonvulsant agents.

(Am J Dis Child 131:546-550, 1977)

Author Affiliations
From St Luke's Episcopal Hospital, Houston (Dr Hill) and the Department of Pediatrics (Drs Hill and Verniaud and Ms Morgan) and Institute for Lipid Research (Mss Morgan and Nowlin and Dr Horning), Baylor College of Medicine, Houston.

Footnotes
Accepted for publication March 13, 1976.

Reprint requests to Chief of Newborn Research, St Luke's Episcopal Hospital, PO Box 20269, Houston, TX 77030 (Dr Hill).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?