Hypopituitarism following extirpation of a pharyngeal pituitary
F. T. Weber, W. H. Donnelly Jr and R. L. Bejar
A neonate without external malformation had undergone removal of a
nasopharyngeal mass containing anterior and posterior pituitary tissue.
Numerous endocrine evaluations since that time have confirmed polyhormonal
hypopituitarism. Endocrine replacement has resulted in a healthy, normal
child except for short stature. The literature dealing with pharyngeal
pituitary, congenital absence of the pituitary, cyclopia, and other
malformations of the pituitary suggests only vague theories to explain the
infrequent anomalies found in this area. We propose that laminagrams of the
sphenoid of newborns with sighus may aid in early diagnosis and appropriate
replacement therapy.
