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Hiroshi Shiono, MD; Jun-Ichi Kadowaki; Hiromi Tsuneta; Bunsaku Nagai; Haruo Nanbu

Am J Dis Child. 1977;131(5):522-524.

Abstract
• The case presented here may be the first identified report of Down syndrome with 21 trisomy in one child of triplets. One triplet died at 1 month of age; his facial appearance was not typical of Down syndrome. Detailed testing of blood groups suggested identical origin in the remaining two children. However, the fluorescent banding technique of chromosome, one-way mixed lymphocyte culture test, and HLA typing were suggestive of dizygotic origin. Skin transplant studies supported this contention.

(Am J Dis Child 131:522-524, 1977)

Author Affiliations
From the Departments of Pediatrics (Dr Kadowaki) and Legal Medicine (Dr Shiono), National Nishi-Sapporo Hospital, and Shakai-Hoken-Chuoo Hospital (Drs Tsuneta, Nagai, and Nanbu), Sapporo, Japan.

Footnotes
Reprint requests to Department of Legal Medicine, Sapporo Medical College, S1 W 17, Chuoku, Sapporo, Japan (Dr Shiono).

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