This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Raymond L. Hansen, MD; James J. Marx, PhD; Louis J. Ptacek, MD; Ronald C. Roberts, PhD

Am J Dis Child. 1977;131(5):518-521.

Abstract
• We describe two brothers with ataxia telangiectasia (AT) of which one was unique in that he had no detectable IgG and IgA concentrations in the serum or saliva. The other brother had the more common IgA deficiency in the serum and saliva. Neither patient had a history of undue sinopulmonary infections. In spite of the absence of these immunoglobulins in the sera, there were cells in the bone marrow and peripheral blood that stained with fluorescein-labeled anti-IgG and anti-IgA. Both patients had demonstrable humoral antibody and cell-mediated immune responses to the antigens tested. We also discuss possible pathophysiological mechanisms causing the above defects.

(Am J Dis Child 131:518-521, 1977)

Author Affiliations
From the Marshfield Clinic and Marshfield Medical Foundation, Inc, Marshfield, Wis.

Footnotes
Reprint requests to Marshfield Medical Foundation, Inc, 510 N St Joseph Ave, Marshfield, WI 54449 (Dr Hansen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?