This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Results of a Nationwide Survey

Nancy J. Hopwood, MD; Frederic M. Kenny, MD

Am J Dis Child. 1977;131(12):1353-1356.

Abstract
• To establish the incidence of Nelson's syndrome in children treated with total bilateral adrenalectomy (TBA) for Cushing's disease, a survey was made of members of The Lawson Wilkins Pediatric Endocrine Society. Thirty-one patients aged 10 months to 16 years had been treated with TBA for Cushing's disease; one had been treated with ortho para prime isomer of dichlorodiphenyldichloroethane alone. Postadrenalectomy hyperpigmentation was reported in 18 patients. Sella enlargement was detected in eight patients (25%) after 1 to 5.5 years (mean, three years) post-TBA. Five of these patients have had documented pituitary adenomas to date. This incidence is higher than the adult figure of 10% to 16%.

(Am J Dis Child 131:1353-1356, 1977)

Author Affiliations
From the Children's Hospital of Pittsburgh and the Department of Pediatrics, University of Pittsburgh. Dr Hopwood is currently with the Department of Pediatrics, University of Michigan Medical Center, Ann Arbor.

Footnotes
Deceased.

Reprint requests to Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109 (Dr Hopwood).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Corticotroph Tumor Progression after Adrenalectomy in Cushing's Disease: A Reappraisal of Nelson's Syndrome
Assie et al.
J. Clin. Endocrinol. Metab. 2007;92:172-179.
ABSTRACT | FULL TEXT  

Neurosurgical Treatment of Nelson's Syndrome
Kelly et al.
J. Clin. Endocrinol. Metab. 2002;87:5465-5469.
ABSTRACT | FULL TEXT