Somatomedin and growth hormone in the newborn

doi:10.1001/archpedi.131.11.1249

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Vol. 131 No. 11, November 1977

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Somatomedin and growth hormone in the newborn

R. L. Hintz, J. M. Seeds and R. E. Johnsonbaugh

Somatomedin (SM) levels were measured by porcine cartilage bioassay, and growth hormone (GH) levels by radioimmunoassay in 52 full-term umbilical cord plasma samples and 28 maternal plasma samples. The SM levels in cord plasmas was 0.50 +/- 0.19 units/ml (mean +/- SD) compared to an adult standard plasma pool of 1.0 units/ml. The cord GH levels were 41.7 +/- 36 mmicrogram/ml. The low relative value of SM in the cord plasma is consistent with that found during early childhood, and may reflect a lower level of requirement. The high neonatal GH levels are hypothesized to be a compensatory increase to overcome factors suppressing SM production in fetal life.

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