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Associated With Coronary Artery Disease

Alfred J. Pennisi, MD; Eva T. Heuser, MD; Max R. Mickey, PhD; Allen Lipsey, MD; Mohammad H. Malekzadeh, MD; Richard N. Fine, MD

Am J Dis Child. 1976;130(9):957-961.

Abstract
• Fasting serum cholesterol and serum triglyceride levels were determined in 15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients. Fourteen of 15 MH patients (93%) had elevated triglyceride levels (>140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P <.001). Two of 15 MH patients (13%) had elevated cholesterol levels (>230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P =.03). In MH patients, a positive correlation was noted between serum triglyceride levels and carbohydrate intake (P =.03). Autopsy material from 12 children who underwent MH or RT was compared to material from 16 age-matched controls; an increased collagenous content of intima, a possible early indicator of coronary artery disease, was noted more frequently (P <.006) in index patients compared to controls. Our data demonstrate that hyperlipidemia is a frequent finding in pediatric patients treated with MH and RT, and may be associated with premature coronary artery disease.

(Am J Dis Child 130:957-961, 1976)

Author Affiliations
From the departments of pediatrics (Drs Pennisi, Fine, and Malekzadeh) and pathology (Drs Heuser and Lipsey), University of Southern California School of Medicine and the Dialysis and Transplant Program, Childrens Hospital of Los Angeles, and the School of Medicine, Biomathematics, University of California at Los Angeles (Dr Mickey).

Footnotes
Received for publication Jan 23, 1976; accepted May 14.

Reprint requests to Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90054 (Dr Pennisi).

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