Hyperlipidemia in pediatric hemodialysis and renal transplant patients. Associated with coronary artery disease
A. J. Pennisi, E. T. Heuser, M. R. Mickey, A. Lipsey, M. H. Malekzadeh and R. N. Fine
Fasting serum cholesterol and serum triglyceride levels were determined in
15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients.
Fourteen of 15 MH patients (93%) had elevated triglyceride levels (greater
than 140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P less than
.001). Two of 15 MH patients (13%) had elevated cholesterol levels (greater
than 230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P = .03). In
MH patients, a positive correlation was noted between serum triglyceride
levels and carbohydrate intake (P = .03). Autopsy material from 12 children
who underwent MH or RT was compared to material from 16 age-matched
controls; an increased collagenous content of intima, a possible early
indicator of coronary artery disease, was noted more frequently (P less
than .006) in index patients compared to controls. Our data demonstrate
that hyperlipidemia is a frequent finding in pediatric patients treated
with MH and RT, and may be associated with premature coronary artery
disease.
