Hyperuricemia in the hemolytic-uremic syndrome
B. S. Kaplan and P. D. Thomson
Elevated serum uric acid concentrations were found in 18 children with
hemolytic-uremic syndrome. The highest recorded level in each patient
ranged from 10 to 29 mg/100 ml, and nine patients had concentrations of
greater than 20 mg/100 ml. During a 53-hour period of peritoneal dialysis,
5.5 gm of uric acid was removed from one infant. Although acute renal
failure was probably the major factor, erythrocyte destruction and
hyperlacticacidemia may also have been important in the pathogenesis of the
hyperuricemia.
