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Fatal Disseminated BCG InfectionAn Investigation of the Immunodeficiency
Justen Passwell, MB, ChB, MRCP;
David Katz, MB, ChB;
Yitzhak Frank, MD;
Zvi Spirer, MD;
Bernard E. Cohen, MB, ChB, FRCP(E);
Micha Ziprkowski, MD
Am J Dis Child. 1976;130(4):433-436.
Abstract
• A 2-year-old boy had a fatal disseminated BCG infection. Immunologic assessment showed a normal humoral response and normal numbers of E rosettes, normal thymus weight and histological features, but an abnormal response of lymphocytes in vitro and negative skin tests. Histological examination showed the presence of Gram-negative acid-fast bacilli within the macrophages. The possible mechanisms of immunodeficiency in this patient are discussed.
(Am J Dis Child 130:433-436, 1976)
Author Affiliations
From the departments of pediatrics "B" (Drs Passwell, Frank, Cohen, and Ziprkowski) and pathology (Dr Katz), the Chaim Sheba Medical Center, the Department of Pediatrics (Dr Spirer), Hadassah Municipal Hospital, and the Tel Aviv University Sackler School of Medicine, Israel.
Footnotes
Received for publication Jan 10, 1975; accepted April 22.
Reprint requests to Department of Pediatrics "B," the Chaim Sheba Medical Center, Tel-Hashomer, Israel (Dr Cohen).
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