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Four Familial Cases With Long-Term Follow-Up and Perspective

Dorothy R. Hollingsworth, MD; C. Charlton Mabry, MD

Am J Dis Child. 1976;130(2):148-155.

Abstract
• Congenital Graves disease has been described as a transient disorder in which the mother has or has had hyperthyroidism. Experience with four affected children to ages 5 to 9 years and a review of published cases led us to conclude that long-acting thyroid stimulator (half-life, six days) is not the cause of the disease. This disease occurs in infants from families with a high incidence of Graves disease, and, in many, hyperthyroidism persists for months or years. The pathogenesis of Graves disease is unknown, and the simplistic maternal-to-fetal humoral theory is not a suitable explanation for congenital Graves disease. If Graves disease is considered in the larger perspective than the maternal-fetal unit, a pattern of inheritance is apparent, ie, an autosomal-dominant trait with a predilection for the female individual.

(Am J Dis Child 130:148-155, 1976)

Author Affiliations
From the Department of Pediatrics, University of Kentucky, Lexington.

Footnotes
Received for publication March 28, 1975; accepted May 27.

Read in part before the Kroc Foundation Symposium on Maternal-Fetal Thyroid Function, Santa Ynez, Calif, Nov 10-13, 1974.

Reprint requests to Department of Pediatrics, University of Kentucky, Lexington, KY 40506 (Dr Hollingsworth).

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