This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Vitamin A Metabolism and Effect on Cerebrospinal Fluid Pressure

Rosalind S. Abernathy, MD

Am J Dis Child. 1976;130(12):1360-1362.

Abstract
• A 5-month-old infant had the single problem of a bulging fontanelle. A diagnosis of cystic fibrosis with secondary hypovitaminosis A was made by the findings of high sweat chloride values and a low serum carotene level. A greatly accelerated rate of weight gain following the addition of pancreatic enzyme supplements confirmed the presence of malabsorption. The infant developed characteristic cystic fibrosis pulmonary disease at 20 months of age.

Animal studies have shown vitamin A deficiency to be associated with increased cerebrospinal fluid (CSF) pressure, diminished absorption of CSF, and pathological findings of thickening and infiltration with mucopolysaccharides of the dura mater around the arachnoid villi.

(Am J Dis Child 130:1360-1362, 1976)

Author Affiliations
From the Cystic Fibrosis Center, University of Arkansas Medical Center, Little Rock.

Footnotes
Reprint requests to Cystic Fibrosis Center, University of Arkansas Medical Center, 4301 W Markham St, Little Rock, AR 72201 (Dr Abernathy).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute Hydrocephalus Masquerading as Catch-Up Head Growth in an Infant with Cystic Fibrosis
Campellone et al.
CLIN PEDIATR 1995;34:436-439.
 

Initial Treatment of Cystic Fibrosis: Frequency of Transient Bulging Fontanel
Roach and Sinal
CLIN PEDIATR 1989;28:371-373.
ABSTRACT