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An Evolving Therapeutic Regimen

Roger M. Barkin, MD; Charles C. Greer, MD; Cajsa J. Schumacher, MD; Kenneth McIntosh, MD

Am J Dis Child. 1976;130(12):1318-1321.

Abstract
• Ampicillin sodium has been the drug of choice in the treatment of Haemophilus influenzae meningitis. The development of ampicillin-resistant strains forces the clinician to focus on alternative therapies. We describe two patients in whom neutropenia was noted secondary to chloramphenicol administration, and streptomycin sulfate and sulfonamides were employed. An historical perspective summarizing the evolution of available therapeutic regimens is presented.

(Am J Dis Child 130:1318-1321, 1976)

Author Affiliations
From the Department of Pediatrics, University of Colorado Medical Center, Denver.

Footnotes
Reprint requests to Department of Pediatrics, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80220 (Dr Barkin).

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Streptomycin and Sulfisoxazole for Treatment of Haemophilus influenzae Meningitis
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ABSTRACT