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Hypokalemia Associated With Antibiotic TreatmentEvidence in Children With Malignant Neoplasms
F. Bruder Stapleton, MD;
Bryan Nelson, MD;
T. S. Vats, MD;
Michael A. Linshaw, MD
Am J Dis Child. 1976;130(10):1104-1108.
Abstract
• A patient with acute lymphocytic leukemia developed hypokalemia during two separate courses of antibiotic therapy. In a review of 33 children from our institution with various malignant neoplasms, 24 of 48 antibiotic courses were associated with hypokalemia that could not be explained by gastrointestinal fluid losses. Carbenicillin disodium, gentamicin sulfate, and methicillin sodium or nafcillin sodium combination therapy was associated with hypokalemia in 23 of 35 courses in which serum electrolytes were monitored. No correlation between hypokalemia and the stage of the basic disease or the use of antineoplastic agents was found with this antibiotic combination. Our data and a review of the literature suggest that carbenicillin produces hypokalemia through an impermeant anion effect on the renal tubule. Children receiving carbenicillin should be monitored with frequent serum potassium determinations.
(Am J Dis Child 130:1104-1108, 1976)
Author Affiliations
From the sections of pediatric nephrology (Drs Stapleton and Linshaw) and pediatric hematology (Dr Vats), Department of Pediatrics (Dr Nelson), University of Kansas Medical Center, Kansas City.
Footnotes
Accepted for publication Feb 7, 1976.
Reprint requests to Section of Pediatric Nephrology, Department of Pediatrics, University of Kansas Medical Center, 39th Street at Rainbow Boulevard, Kansas City, KS 66103 (Dr Stapleton).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Another Form of Iatrogenic Hypokalemia
Danilevicius
JAMA 1976;236:2657-2657.
ABSTRACT
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