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Nosocomial and Maternally Acquired Herpesvirus Hominis InfectionsA Report of Four Fatal Cases in Neonates
Donald P. Francis, MD;
Kenneth L. Herrmann, MD;
James R. MacMahon, MD;
Katherine H. Chavigny, MS;
Karen C. Sanderlin, MS
Am J Dis Child. 1975;129(8):889-893.
Abstract
• Four fatal cases of neonatal herpes simplex infection occurred during a two-month period in the perinatal intensive care unit of a hospital. Virus isolation or serologic studies, or both, implicated herpesvirus hominis type 2 in all four cases. Three of the infants developed symptoms in the first week of life and were probably infected in utero or at delivery. The fourth infant did not develop signs of illness until age 6 weeks, an interval much longer than that expected with disease acquired at birth. An epidemiologic investigation indicated that the most likely source of this fourth infant's herpes infection was by indirect contact with one of the other three infected neonates. Nosocomial spread of herpes simplex virus within a hospital nursery, although uncommon, may pose an added risk to the newborn infant if nursery techniques among infants are compromised.
(Am J Dis Child 129:889-893, 1975)
Author Affiliations
From the bureaus of epidemiology (Dr. Francis) and laboratories (Dr. Herrmann and Ms. Sanderlin), Center for Disease Control, Public Health Service, US Department of Health, Education and Welfare, Atlanta; and the University of Oregon Medical School, Portland (Dr. MacMahon and Ms. Chavigny).
Footnotes
Received for publication June 27, 1974; accepted Sept 9.
Reprint requests to Virology Division, Department of Health, Education and Welfare, Public Health Service, Center for Disease Control, Atlanta, GA 30333 (Dr. Herrmann).
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