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John J. Hutter, Jr., MD; William E. Hathaway, MD

Am J Dis Child. 1975;129(5):641-643.

Abstract
A 6-year-old girl had chronic thrombocytopenia and substantial platelet function abnormality associated with detectable IgM antiplatelet antibody. Treatment with prednisone was followed by an improvement in bleeding time, although in vitro platelet function deteriorated. This observation suggests an effect of prednisone on hemostasis that is independent of platelet function. Further trials of prednisone in patients with similar platelet function abnormalities who have a substantial bleeding tendency would appear indicated.

Author Affiliations
From the Department of Pediatrics, University of Colorado Medical Center, Denver.

Footnotes
Received for publication May 28, 1974; accepted Aug 14.

Reprint requests to Department of Pediatrics, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, CO 80220 (Dr. Hathaway).

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