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Report of Three Cases

Balu H. Athreya, MD; Patricia Borns, MD; Mary L. Rosenlund, MD

Am J Dis Child. 1975;129(5):634-637.

Abstract
Three patients with cystic fibrosis were noted to have swelling of knee and ankle joints during exacerbation of their lung disease. Synovial fluid was analyzed in one patient and the synovium underwent biopsy in another. These studies excluded other causes of arthritis but did not contribute any new information on the nature of secondary hypertrophic osteoarthropathy. Radiological examination of long bones confirmed the diagnosis of hypertrophic osteoarthropathy in all three patients. Since many patients with cystic fibrosis survive longer, more instances of hypertrophic osteoarthropathy are expected in the future.

Author Affiliations
From the Arthritis Clinic and the Cystic Fibrosis Clinic, Children's Hospital of Philadelphia (Drs. Athreya and Rosenlund); and Children's Seashore House, Atlantic City, NJ (Dr. Athreya).

Footnotes
Received for publication May 9,1974; accepted Aug 19.

Reprint requests to Children's Seashore House, 4100 Atlantic Ave, Atlantic City, NJ 08401 (Dr. Athreya).

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