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Treatment With Transfer Factor

William A. Sellars, MD; Mary Ann South, MD

Am J Dis Child. 1975;129(5):622-627.

Abstract
An 18-year-old boy with Wiskott-Aldrich syndrome has severe symptoms of thrombocytopenia, recurrent infections, and atopic eczema. We believe he is the fifth oldest patient described with Wiskott-Aldrich syndrome. Recently, a malignant lymphoma of the histiocytic type appeared in the skin, while he was receiving transfer factor. To our knowledge, he is the only reported patient with lymphoma in the skin, but four other patients with Wiskott-Aldrich syndrome have developed malignant lymphoreticular lymphoma during transfer factor therapy. Detailed immunologic studies show failure to make a sustained antibody response to various antigens, lack of delayed hypersensitivity responsiveness, and failure of proliferative response to antigens in in vitro cultures. The IgE and IgA levels were high, and the IgM and IgG levels were low. Although clinical improvement followed transfer factor therapy, development of the malignant lymphoma was not prevented.

Author Affiliations
From the departments of pediatrics, University of Texas Southwestern Medical School, Dallas, and Baylor College of Medicine, Houston.

Footnotes
Received for publication April 8, 1974; accepted July 11.

Reprint requests to 638 W Tenth, Dallas, TX 75208 (Dr. Sellars).

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