This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Norman L. Virnig, MD; John W. Reynolds, MD

Am J Dis Child. 1974;128(2):186-190.

Abstract
Detailed attempts to isolate pathogens were made during an apparent epidemic outbreak of neonatal necrotizing enterocolitis (NEC). In addition, all cases of infants with this disease since 1964 were reviewed for comparison with the present outbreak. Efforts were made to determine a transmissible cause. No bacteria, virus, or fungus common to the infants involved in the outbreak was isolated. Neither could any other transmissible cause be implicated. It appears that the organisms involved in NEC are normal bowel flora that enter the peritoneum and blood stream through an altered gut mucosa.

Author Affiliations
From the St. Paul Children's Hospital Newborn Center, and the Department of Pediatrics, University of Minnesota Medical School.

Footnotes
Received for publication Oct 1, 1973; accepted Feb 11, 1974.

Reprint requests to the Department of Pediatrics, St. Paul-Ramsey Hospital, 640 Jackson St, St. Paul, MN 55101 (Dr. Virnig).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Necrotizing Enterocolitis: Feeding in Endemic and Epidemic Periods
Zabielski et al.
JPEN J Parenter Enteral Nutr 1989;13:520-524.
ABSTRACT  

Infections Acquired by Young Infants
Maguire et al.
Arch Pediatr Adolesc Med 1981;135:693-698.
ABSTRACT  

Necrotizing Enterocolitis: Epidemic Following an Outbreak of Enterobacter cloacae Type 3305573 in a Neonatal Intensive Care Unit
Powell et al.
Arch Pediatr Adolesc Med 1980;134:1152-1154.
ABSTRACT  

Epidemic Occurrence of Neonatal Necrotizing Enterocolitis
Guinan et al.
Arch Pediatr Adolesc Med 1979;133:594-597.
ABSTRACT  

Oral Gentamicin Therapy in the Prevention of Neonatal Necrotizing Enterocolitis: A Controlled Double-Blind Trial
Grylack and Scanlon
Arch Pediatr Adolesc Med 1978;132:1192-1194.
ABSTRACT  

Human Milk and the Small Premature Infant
Fomon et al.
Arch Pediatr Adolesc Med 1977;131:463-467.
ABSTRACT