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Rapidly Fatal Course of Leigh Disease in a 5-year-old Child

Marvin A. Eisengart, MD; James M. Powers, MD; Arthur L. Rose, MD, ChB

Am J Dis Child. 1974;127(5):730-732.

Abstract
A previously normal, 5-year-old boy developed a rapidly progressive neurological illness three days following diagnosis and treatment of a streptococcal pharyngitis. He had quadriparesis, then developed pseudobulbar palsy and respiratory failure, and died eight weeks later. At postmortem examination, the neuropathological findings were diagnostic of subacute necrotizing encephalomyelopathy, a disease primarily of infancy, which when present in older children almost always follows the course of a chronic neurological illness.

Author Affiliations
Bronx, NY

From the departments of neurology and pediatrics (Drs. Eisengart and Rose), and pathology (Dr. Powers), Albert Einstein College of Medicine of Yeshiva University, Bronx, NY.

Footnotes
Received for publication July 5, 1973; accepted Sept 24.

Reprint requests to Pediatric Neurology, Rm 341, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Pkwy S, Bronx, NY 10461 (Dr. Eisengart).

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