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Plasma Levels in Mothers and Their Premature Infants With Neonatal Hypocalcemia

John F. Rosen, MD; Martin Roginsky, MD; Gerald Nathenson, MD; Laurence Finberg, MD

Am J Dis Child. 1974;127(2):220-223.

Abstract
Plasma levels of 25-hydroxyvitamin D (25-OHD) have been measured in mothers and their premature infants with neonatal hypocalcemia. In 11 of 15 mother-premature pairs, plasma levels of 25-OHD were remarkably low in both mother and infant. The present data suggest a nutritional basis for the abnormal biochemical findings in these mothers. Secondary vitamin D deficiency in premature infants of these mothers appears to play a significant, but not exclusive, role in the pathogenesis of this syndrome. During pregnancy, nutritional vitamin D deficiency may be more common in this population than is currently realized.

Author Affiliations
Bronx, NY

From the Department of Pediatrics, Montefiore Hospital and Medical Center, Morrisania City Hospital and the Albert Einstein College of Medicine, Bronx, NY (Drs. Rosen, Nathenson, and Finberg), and the Department of Medicine, Nassau County Medical Center, New York (Dr. Roginsky).

Footnotes
Received for publication July 12, 1973; accepted Sept 13.

Read in part before the annual meeting of the American Institute of Nutrition and the American Society for Clinical Nutrition, New York, Aug 17, 1973.

Reprint requests to Montefiore Hospital and Medical Center, Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY 10467 (Dr. Rosen).

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