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Carboxyhemoglobin Determination in Evaluating Neonatal Jaundice
MAJ Errol R. Alden, MC;
Sean R. Lynch, MD;
Richard P. Wennberg, MD
Am J Dis Child. 1974;127(2):214-217.
Abstract
Carboxyhemoglobin levels were higher in patients with hemolytic disease (Rh isoimmunization) than in normal infants born of nonsmoking mothers, both at birth and during the first day of life. In these patients, postnatal carboxyhemoglobin levels correlated with the rate of bilirubin rise and the need for exchange transfusion. Nine infants with idiopathic hyperbilirubinemia and normal carboxyhemoglobin levels had no evidence for increased hemolysis, whereas seven jaundiced infants with elevated carboxyhemoglobin concentrations had conditions likely to cause hemolysis.
Carboxyhemoglobin determination may be helpful in (1) predicting the need for exchange transfusion in erythroblastotic infants and (2) differentiating hemolytic from nonhemolytic causes of neonatal jaundice.
Author Affiliations
USA, Fort Lewis, Wash; Seattle
From the departments of pediatrics (Drs. Alden and Wennberg) and medicine (Dr. Lynch), University of Washington School of Medicine, Seattle. Dr. Alden is now with the Newborn Service, Madigan Army Medical Center, Fort Lewis, Wash. Dr. Lynch is now with the Department of Medicine, University of Witwatersrand, Johannesburg, South Africa.
Footnotes
Received for publication June 14, 1973; accepted Aug 22.
Reprint requests to Department of Pediatrics RD-20, University of Washington, Seattle 98195 (Dr. Wennberg).
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