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Blaise E. Favara, MD; Ralph A. Franciosi, MD; L. Joseph Butterfield, MD

Am J Dis Child. 1974;127(2):197-204.

Abstract
The syndrome of disseminated intravascular and vegetative cardiac thrombosis occurred in 24 neonates. The syndrome, characterized by platelet thrombosis and cardiac valve platelet masses, is distinctly different from disseminated intravascular coagulation and resultant fibrin deposition in blood vessels without cardiac valve involvement. Speculations on cause and pathogenesis are made, and possible detrimental effects of heparin therapy are pointed out, since the disorder is one of platelet thrombosis rather than coagulation and fibrin development.

Author Affiliations
Denver

From the Department of Pathology (Drs. Favara and Franciosi) and Newborn Center (Dr. Butterfield), Children's Hospital, Denver.

Footnotes
Received for publication April 28, 1973; accepted Sept 11.

Read before the First Pan-American Reunion of Pediatric Pathologists, Mexico City, Jan 6, 1973.

Reprint requests to Department of Pathology, Children's Hospital, 1056 E 19th Ave, Denver 80218 (Dr. Favara).

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