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With Myocardial Infarction Before Age 50

Charles J. Glueck, MD; Ronald W. Fallat, MD; Reginald Tsang, MB, BS; Charles R. Buncher, ScD

Am J Dis Child. 1974;127(1):70-75.

Abstract
We studied 223 children from 70 families where one parent had a myocardial infarction before age 50 to assess the frequency of hyperlipemia in children prone to atherosclerosis on the basis of family history. Familial hyperlipoproteinemia was documented in 60 of 70 (85%) of the myocardial infarction kindreds with predominant phenotypes for II-A, II-B, and IV hyperlipoproteinemia in 14, 18, and 28 kindreds, respectively. Familial hyperlipoproteinemia was documented in 69 of 223 (31%) children from kindreds with myocardial infarction, with phenotypes II-A, II-B, and IV hyperlipoproteinemia in 34, 10, and 25 children, respectively. The common occurrence of familial hyperlipoproteinemia in progeny of parents with myocardial infarction before age 50 enables early recognition and treatment of increased plasma cholesterol and triglyceride, and emphasizes the importance of questions about premature myocardial infarction in the pediatric family history.

Author Affiliations
Cincinnati

From the Lipoprotein Research Laboratory, General Clinical Research Center, Cincinnati General Hospital (Drs. Glueck and Fallat); Fels Division of Pediatric Research and Newborn Division, Children's Hospital Research Foundation (Dr. Tsang); and the Division of Biostatistics and Epidemiology, University of Cincinnati, School of Medicine (Dr. Buncher).

Footnotes
Received for publication May 31, 1973; accepted Aug 13, 1973.

Reprint requests to General Clinical Research Center, Cincinnati General Hospital, 234 Goodman St, Room C 2-3, Cincinnati 45229 (Dr. Glueck).

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