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Anna M. Sesso, MD; Robert C. Snyder, MD; Clifford E. Schott, MD

Am J Dis Child. 1973;126(6):847-849.

Abstract
A 26-month-old girl ingested 250 mg of imipramine hydrochloride (Tofranil). She developed respiratory arrest, convulsions, coma, and four episodes of cardiac asystole and had eight episodes of ventricular fibrillation. Propranolol hydrochloride (Inderal) effectively converted the fibrillation to normal sinus rhythm after seven failures with the use of direct-current defibrillation. Continuous gastric lavage, mechanical ventilation, and symptomatic therapy contributed to a favorable outcome.

Author Affiliations
Philadelphia

From the departments of pediatrics and medicine, Mercy Catholic Medical Center, Philadelphia. Dr. Snyder is now a pathology resident at the Hospital of the University of Pennsylvania, Philadelphia.

Footnotes
Received for publication April 6, 1973; accepted Aug 3.

Reprint requests to Mercy Catholic Medical Center, Misericordia Division, 54th Street and Cedar Avenue, Philadelphia 19143 (Dr. Sesso).

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