This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Josette W. Bianchine, MD

Am J Dis Child. 1973;126(6):823-826.

Abstract
Two children were born in a sibship of four following two early spontaneous abortions. One has Noonan syndrome and the other trisomy 21 mongolism. Their mother, who was 38 and 41 years old, respectively, at the time of their births, had also been exposed to an undetermined dosage of abdominal and pelvic radiation. Since the cause of Noonan syndrome has remained an enigma, we describe these two siblings in the hope of shedding some light on the pathogenesis of this well-defined nosologic entity.

Author Affiliations
Lubbock, Tex

From the departments of pediatrics, Baltimore City Hospitals; the Johns Hopkins University School of Medicine; and the US Public Health Service Hospital, Baltimore.

Footnotes
Received for publication June 29, 1973; accepted July 9.

Reprint requests to Texas Tech University School of Medicine, PO Box 4569, Lubbock, TX 79409 (Dr. Bianchine).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?