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Amanullah Khan, MD, PhD; Joseph M. Hill, MD; Ellen Loeb, MD; Ayten MacLellan, MD; Norwood O. Hill, MD

Am J Dis Child. 1973;126(6):797-799.

Abstract
A 1-year-old white girl with typical signs and symptoms of Chédiak-Higashi syndrome showed impaired delayed hypersensitivity. The patient had frequent upper respiratory tract infections in the past, including an attack of viral pneumonia. Transfer factor prepared from 2 x 10⁸ normal lymphocytes was given intramuscularly. Following this, the patient developed delayed hypersensitivity responses. Passive transfer of histoplasmin reactivity from the donor to the recipient was also accomplished. The patient exhibited evidence of improved immunity.

Author Affiliations
Dallas

From the departments of immunotherapy (Dr. Khan) and hematology (Drs. Hill, Loeb, MacLellan, and Hill) of the Wadley Institutes of Molecular Medicine, and the Granville C. Morton Cancer and Research Hospital, Dallas.

Footnotes
Received for publication Nov 29, 1972; accepted May 21, 1973.

Reprint requests to Wadley Institutes of Molecular Medicine, 9000 Harry Hines, Dallas, 75235 (Dr. Khan).

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