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Clinical Improvement in Two Siblings

Richard C. Talamo, MD; Murray Feingold, MD

Am J Dis Child. 1973;125(6):845-847.

Abstract
Two male siblings had the onset of liver disease in the early months of life; cirrhosis was demonstrated on open liver biopsy in one, and both were found to have hereditary ZZ alpha1-antitrypsin deficiency in a family genetic study.

Both infants have shown significant improvement and are clinically well at the ages of 18 months and 3 years, respectively. The infantile cirrhosis associated with severe alpha1-antitrypsin deficiency does not necessarily pursue a continuous, relentless, down-hill course.

Author Affiliations
Boston

From the Department of Pediatrics, Harvard Medical School, Children's Service, Massachusetts General Hospital (Dr. Talamo), and the Department of Pediatrics, Tufts University School of Medicine, Center for Genetic Counseling and Birth Defect Evaluation, Boston Floating Hospital (Dr. Feingold).

Footnotes
Received for publication Aug 3, 1972; accepted Feb 2, 1973.

Reprint requests to the Massachusetts General Hospital, Fruit St, Boston, MA 02114 (Dr. Talamo).

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