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Defective Phagocytosis Due to Tuftsin Deficiency in Splenectomized Subjects
Andreas Constantopoulos, MD;
Victor A. Najjar, MD;
Jay B. Wish;
Thomas H. Necheles, MD;
Leo L. Stolbach, MD
Am J Dis Child. 1973;125(5):663-665.
Abstract
The activity of the phagocytosis stimulating peptide, tuftsin, was decreased in the serum of 18 of 23 splenectomized patients. Three of the splenectomized subjects with normal or near-normal tuftsin activity had had traumatic rupture of the spleen. Decreased tuftsin activity was also demonstrated in three patients with sickle-cell disease and in two adults with chronic granulocytic leukemia. Intermediate activity was measured in three patients with chronic lymphocytic leukemia and one patient with β-thalassemia.
Author Affiliations
Boston
From the Department of Pediatrics (Drs. Najjar and Necheles), the Division of Protein Chemistry and the Department of Molecular Biology and Microbiology (Drs. Constantopoulos and Najjar and Mr. Wish), and the Department of Medicine (Dr. Stolbach), Tufts University School of Medicine; and the Boston Floating Hospital for Infants and Children (Drs. Najjar and Necheles), Boston; and Pondville Hospital, Walpole, MA (Dr. Stolbach).
Footnotes
Received for publication May 10, 1972; accepted Dec 18.
Reprint requests to Tufts University School of Medicine, Division of Protein Chemistry, 136 Harrison Ave, Boston 02111 (Dr. Najjar).
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