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A Second Clinical Trial

COL James W. Bass, MC, USA; MAJ Thomas M. Cashman, MC, USA; MAJ Alvin L. Frostad, MC, USA; MAJ Ronald M. Yamaoka, MC, USA; MAJ Richard A. Schooler, MC, USA; LTC Edwin P. Dierdorff, MC, USA

Am J Dis Child. 1973;125(3):397-402.

Abstract
Four antimicrobial regimens were compared in the treatment of acute otitis media in children. One hundred children each received (1) phenoxymethyl penicillin, 75 mg/kg/day, (2) the same dose of penicillin phenoxymethyl plus sulfisoxazole, 150 mg/ kg/day, (3) erythromycin estolate, 50 mg/kg/day, or (4) ampicillin trihydrate, 75 mg/kg/day, all orally in four divided doses daily for ten days.

Patients were evaluated at two, seven, and 14 days for therapeutic response in a double-blind manner and no significant differences were noted among the four treatment groups. Ninety-four percent and 83% of patients had antimicrobial activity in their urine at two and seven days indicating good compliance in taking their medications and no difference in compliance was noted among treatment groups relevant to treatment results.

Author Affiliations
Honolulu

From the Department of Pediatrics and the Otolaryngology Service of the Department of Surgery, US Army Tripler General Hospital, Honolulu.

Footnotes
Received for publication May 11, 1972; accepted Nov 27.

Reprint requests to the Department of the Army, Headquarters Tripler Army Medical Center, APO San Francisco 96438 (LTC Bass).

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