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Chronic Lead Intoxication in Children

Robert G. Feldman, MD; James Haddow, MD; Louis Kopito, MS; Harry Schwachman, MD

Am J Dis Child. 1973;125(1):39-41.

Abstract
Lead neuropathy has been considered an infrequent occurrence in children with lead intoxication. Acute encephalopathy may overshadow its recognition, but chronic exposure to lead may produce changes in peripheral nerve fibers that result in altered conduction characteristics. In this study 24 Boston children with known plumbism were found to have reduced mean motor nerve conduction velocities as compared with normal children. This finding may provide a valuable test for discovering minimal peripheral neurotoxic effects of chronic exposure to lead ingestion.

Author Affiliations
Boston

From the departments of neurology (Dr. Feldman) and pediatrics (Dr. Haddow), Boston University School of Medicine, the Boston Veterans Administration Hospital (Dr. Feldman), and the Boston City Hospital (Dr. Haddow); the Department of Pediatrics (Mr. Kopito and Dr. Schwachman), Harvard University Medical School; and the Department of Medicine (Mr. Kopito and Dr. Schwachman), Childrens Hospital Medical Center, Boston.

Footnotes
Received for publication March 15, 1972; accepted Aug 3.

Reprint requests to 80 E Concord St, Boston 02118 (Dr. Feldman).

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ABSTRACT