This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

James W. French, MD; Beverly C. Morgan, MD; Warren G. Guntheroth, MD

Am J Dis Child. 1972;123(5):480-484.

Abstract
Recent reports suggest that sudden infant death syndrome (SIDS) may be related to an inappropriate diving reflex or obligate nose breathing. Immersion of the neonatal monkey's face in cold (14 C) water, or nasal occlusion resulted in apnea which is occasionally persistent, bradycardia, and relative hypertension. In the same monkeys at an older age, apnea never persisted after removal of the diving stimulus, and there was no obligate nose breathing. The study documents a dive reflex and obligate nose breathing and concludes that the infant monkey is a suitable model for the study of SIDS. We suggest, however, that the fatal factor in crib death may be the failure to interrupt apnea however the apnea was initiated. The failure to resume respiration may represent an inappropriate return to the apneic state of the fetus.

Author Affiliations
Seattle

From the Department of Pediatrics and the Regional Primate Center, University of Washington School of Medicine, Seattle.

Footnotes
Received for publication Aug 31, 1971; accepted Jan 17, 1972.

Reprint requests to the Department of Pediatrics, University of Washington School of Medicine, Seattle 98195 (Dr. Guntheroth).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Inhibitory effects of hyperthermia on mechanisms involved in autoresuscitation from hypoxic apnea in mice: a model for thermal stress causing SIDS
Kahraman and Thach
J. Appl. Physiol. 2004;97:669-674.
ABSTRACT | FULL TEXT  

Oxygen-sensing neurons in the central nervous system
Neubauer and Sunderram
J. Appl. Physiol. 2004;96:367-374.
ABSTRACT | FULL TEXT  

The Role of Respiratory Infection in Intrathoracic Petechiae: Implications for Sudden Infant Death
Guntheroth et al.
Arch Pediatr Adolesc Med 1980;134:364-366.
ABSTRACT  

Sudden Infant Death Syndrome
SHAW
Arch Pediatr Adolesc Med 1972;124:787-787.
ABSTRACT