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Absence of Growth Potentiation

Joseph C. Schutt-Aine, MD; Allan L. Drash, MD

Am J Dis Child. 1972;123(5):475-479.

Abstract
The present study was undertaken to investigate the possible potentiating effect of human placental lactogen (HPL) on human growth hormone (HGH). Five preadolescent hypopituitary patients, aged 6 to 12 years received, at random, three different four month courses of therapy consisting of 1 unit of HGH, 2 units of HGH, and a combination of 1 unit of HGH and 400 mg of HPL, every other day. Linear growth was comparable on the three treatment schedules suggesting absence of growth potentiation but the diabetogenic effect of HGH appeared enhanced by HPL.

Author Affiliations
Pittsburgh

From the Department of Pediatrics, Children's Hospital of Pittsburgh. Dr. Schutt-Aine is now with Howard University School of Medicine, Washington, DC.

Footnotes
Received for publication Dec 10, 1971; accepted Jan 24, 1972.

Read in part before the Midwest Society for Pediatric Research, Chicago, November 1970.

Reprint requests to Clinical Study Center, Children's Hospital of Pittsburgh, 125 DeSoto St, Pittsburgh 15213 (Dr. Drash).

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