Human Placental Lactogen and Human Growth Hormone for Hypopituitarism: Absence of Growth Potentiation

doi:10.1001/archpedi.1972.02110110103010

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Vol. 123 No. 5, May 1972

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Human Placental Lactogen and Human Growth Hormone for Hypopituitarism

Absence of Growth Potentiation

Joseph C. Schutt-Aine, MD; Allan L. Drash, MD

Am J Dis Child. 1972;123(5):475-479.

Abstract

The present study was undertaken to investigate the possiblepotentiating effect of human placental lactogen (HPL) on humangrowth hormone (HGH). Five preadolescent hypopituitary patients,aged 6 to 12 years received, at random, three different fourmonth courses of therapy consisting of 1 unit of HGH, 2 unitsof HGH, and a combination of 1 unit of HGH and 400 mg of HPL,every other day. Linear growth was comparable on the three treatmentschedules suggesting absence of growth potentiation but thediabetogenic effect of HGH appeared enhanced by HPL.

Author Affiliations

Pittsburgh

From the Department of Pediatrics, Children's Hospital of Pittsburgh. Dr. Schutt-Aine is now with Howard University School of Medicine, Washington, DC.

Footnotes

Received for publication Dec 10, 1971; accepted Jan 24, 1972.

Read in part before the Midwest Society for Pediatric Research,Chicago, November 1970.

Reprint requests to Clinical Study Center, Children's Hospitalof Pittsburgh, 125 DeSoto St, Pittsburgh 15213 (Dr. Drash).

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