This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Comparison of Cephalexin, Phenoxymethyl Penicillin, and Ampicillin

Maxwell Stillerman, MD; Henry D. Isenberg, PhD; Max Moody, PhD

Am J Dis Child. 1972;123(5):457-461.

Abstract
Results of cephalexin monohydrate and potassium phenoxymethyl penicillin were compared in children with pharyngitis and group A streptococci in two consecutive studies, 1968 to 1969 and 1969 to 1970. Ampicillin anhydrous was included in the first study. The patients were assigned randomly to one of the antibiotics, 0.5 gm daily for ten days. Recurrences, detected by routine weekly cultures, of the original group A streptococcal types within three weeks after end of treatment were classified as failures. The failure rates in the first study were 11% (4/38) for cephalexin, 26% (10/39) for phenoxymethyl penicillin, and 27% (10/27) for ampicillin. The failure rates in the second study were 9% (4/46) for cephalexin and 20% (10/50) for potassium phenoxymethyl penicillin. In the combined studies cephalexin was more effective than potassium phenoxymethyl penicillin (P <.05).

Author Affiliations
New Hyde Park, NY; Atlanta

From the departments of pediatrics and laboratories, Long Island Jewish Medical Center, New Hyde Park, NY (Drs. Stillerman and Isenberg); and the Streptococcus Bacteriology Unit, Center for Disease Control, Atlanta (Dr. Moody). Dr. Moody is now with Wellcome Reagents Division, Burroughs Wellcome Co., Research Triangle Park, NC.

Footnotes
Received for publication Aug 24, 1971; accepted Jan 18, 1972.

Read before the Ninth and Tenth Interscience Conferences on Antimicrobial Agents and Chemotherapy, Washington, DC, Oct 28, 1969, and Chicago, Oct 20, 1970.

Reprint requests to Long Island Jewish Medical Center, New Hyde Park, NY 11040 (Dr. Stillerman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pharmacodynamic Analysis and Clinical Trial of Amoxicillin Sprinkle Administered Once Daily for 7 Days Compared to Penicillin V Potassium Administered Four Times Daily for 10 Days in the Treatment of Tonsillopharyngitis Due to Streptococcus pyogenes in Children
Pichichero et al.
Antimicrob. Agents Chemother. 2008;52:2512-2520.
ABSTRACT | FULL TEXT  

The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis
Pichichero
CLIN PEDIATR 2007;46:3S-16S.
ABSTRACT  

Selecting the Optimal Antibiotic in the Treatment of Group A {beta}-Hemolytic Streptococci Pharyngitis
Casey
CLIN PEDIATR 2007;46:25S-35S.
ABSTRACT  

Meta-analysis of Cephalosporin Versus Penicillin Treatment of Group A Streptococcal Tonsillopharyngitis in Children
Casey and Pichichero
Pediatrics 2004;113:866-882.
ABSTRACT | FULL TEXT  

Efficacy of Cephalexin Two vs. Three Times Daily vs. Cefadroxil Once Daily for Streptococcal Tonsillopharyngitis
Curtin et al.
CLIN PEDIATR 2003;42:519-526.
ABSTRACT  

Comparison Between Cephalexin Two- and Four-Time Per Day Regimens in Group A Streptococcal Pharyngitis
Stillerman et al.
CLIN PEDIATR 1984;23:348-351.
ABSTRACT  

Treatment of Group A Streptococcal Pharyngitis in Children: Results of a Prospective, Randomized Study of Four Antimicrobial Agents
Ginsburg et al.
CLIN PEDIATR 1982;21:83-88.
ABSTRACT  

Penicillin V for Group A Streptococcal Pharyngotonsillitis: A Randomized Trial of Seven vs Ten Days' Therapy
Schwartz et al.
JAMA 1981;246:1790-1795.
ABSTRACT  

Streptococcal Pharyngitis Therapy
NELSON
Arch Pediatr Adolesc Med 1972;124:610-610.
ABSTRACT