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Tritiated Thymidine in Mixed Leukocyte Culture for Deletion of Transplantation Antigen Response

Sydney E. Salmon, MD; Stanley N. Mogerman, MD; Herbert A. Perkins, MD; Beth A. Smith; Robert I. Lehrer, MD; Henry R. Shinefield, MD

Am J Dis Child. 1972;123(2):111-115.

Abstract

Clinical, pathological, and laboratory findings revealed lymphopenic immunodeficiency (Swiss type agammaglobulinemia) in a 3-month-old baby girl. There was no HL-A identical sibling to serve as a donor of immunocompetent cells, and the transplantation of unmodified nonidentical cells could be anticipated to induce the graft vs host (GVH) syndrome. Therefore, a new technique of transplantation was developed that includes the preliminary destruction in vitro of those donor lymphoid cells capable of initiating the GVH syndrome. Unfortunately, the child died of preexisting sepsis before the clinical efficacy of the transplant could be evaluated. However, the procedure may allow use of HL-A nonidentical donors for lymphoid or bone marrow transplantation in immunodeficiency syndromes.

Author Affiliations

From the Department of Medicine and the Cancer Research Institute, School of Medicine, University of California, San Francisco (Dr. Salmon, Ms. Smith, and Dr. Lehrer), Irwin Memorial Blood Bank (Dr. Perkins), and Kaiser Foundation Hospital (Drs. Mogerman and Shinefield), San Francisco.

Footnotes

Reprint requests to Cancer Research Institute, School of Medicine, University of California, San Francisco 94122 (Dr. Salmon).

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