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Loss of Rubella Hemagglutination Inhibition Antibody in Congenital RubellaFailure of Seronegative Children With Congenital Rubella to Respond to HPV-77 Rubella Vaccine
Louis Z. Cooper, MD;
Alfred L. Florman, MD;
Philip R. Ziring, MD;
Saul Krugman, MD
Am J Dis Child. 1971;122(5):397-403.
Abstract
Serial determinations of rubella hemagglutination inhibition (HI) antibody levels were performed on serum specimens obtained from 223 women who had rubella during pregnancy and their 223 children with congenital rubella. The decline in HI antibody following congenital infection was more rapid than following postnatal infection. By the end of five years, 27 of these children no longer had detectable HI antibody, although all mothers still had antibody. Among 270 children with congenital rubella who had reached their fifth birthday, 50 (18.5%) were seronegative. When 19 such seronegative children were given rubella vaccine [HPV]-77 (high-passage virus strain), only two (10%) of them seroconverted. In contrast, 134 of 135 (99%) normal children of the same age seroconverted.
Author Affiliations
New York
From the Department of Pediatrics, New York University School of Medicine, New York.
Footnotes
Received for publication April 19, 1971; accepted June 29.
Read in part before the 80th annual meeting of the American Pediatric Society, Atlantic City, NJ, April 30, 1970.
Reprint requests to Department of Pediatrics, New York University School of Medicine, 550 First Ave, New York 10016 (Dr. Cooper).
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ABSTRACT
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