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Akio Kobayashi, MD; Yoshiro Ohbe, MD

Am J Dis Child. 1971;121(6):515-517.

Abstract
An 8-year-11-month-old girl had protein-losing enteropathy associated with arsenic poisoning; to our knowledge, this is the first such case to be reported. A total dose of about 31 mg of arsenic trioxide was given orally during a two-month period for verrucae planae juveniles of the dorsal surface of the hands. About four weeks later edema, especially of the legs and eyelids, was noted. Jejunal biopsy with a Crosby's capsule revealed an abnormal dilated villus and mild atrophy of the submucosa. The treatment with dimercaprol resulted in improvement of both hypoproteinemia and edema.

Author Affiliations
Tokyo

From the Gastrointestinal Unit, Department of Pediatrics, National Children's Hospital, Tokyo.

Footnotes
Received for publication Oct 20, 1970.

Reprint requests to Department of Pediatrics, National Children's Hospital, Taishido 3-35-31, Setagaya-ku, Tokyo (Dr. Kobayashi).

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