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Oligomeganephronic Renal Hypoplasia

James E. Carter, MB, ChB, FRCP(C); David S. Lirenman, MD, FRCP(C)

Am J Dis Child. 1970;120(6):537-542.

Abstract
The syndrome of congenital bilateral renal hypoplasia with hypertrophy of nephrons has been well documented in the French literature, but has attracted little attention in North America. We have described two patients with clinical and histological features of the disease. The clinical picture is one of progressive chronic renal failure with symptoms of vomiting, fever, and dehydration occurring in early infancy. The essential pathologic features are a reduction in the size of both kidneys, and a decrease in the number but a marked increase in size of the remaining glomeruli. The possible causes of glomerular hypertrophy are briefly discussed.

Author Affiliations
Vancouver, British Columbia, Canada

From the Department of Paediatrics, Section of Paediatric Nephrology, University of British Columbia and the Health Centre for Children, Vancouver, British Columbia, Canada.

Footnotes
Received for publication June 22, 1970.

Read in part before the 39th annual meeting of the Royal College of Physicians and Surgeons of Canada, Montreal, Jan 22, 1970.

Reprint requests to Department of Paediatrics, University of British Columbia, 715 W 12th Ave, Vancouver 9, British Columbia, Canada (Dr. Lirenman).

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