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James J. Corrigan, Jr., MD

Am J Dis Child. 1970;120(4):324-328.

Abstract
The coagulation and fibrinolytic systems were analyzed in 55 patients with autoimmune diseases. Significant changes, which were found exclusively in those patients with clinically active disease, consisted of thrombocytosis, elevated factor V and factor VIII levels, hyperfibrinogenemia, and evidence of activation of the fibrinolytic system. Three patients with systemic lupus erythematosus had thrombocytopenia. The β₁C-globulin was qualitatively low in 11 cases. No correlation between the coagulation or fibrinolytic data and the reduced β₁C-globulin could be made. No patient had laboratory evidence compatible with a consumption-coagulopathy. The study suggests that the changes observed were similar to other inflammatory states and were probably nonspecific in nature.

Author Affiliations
Atlanta

From the Department of Pediatrics, Section of Pediatric Hematology, Emory University School of Medicine, Atlanta.

Footnotes
Received for publication April 7, 1970.

Read in part before the meeting of the Southern Society for Pediatric Research, Richmond, Va, Nov 23, 1969.

Reprint requests to Department of Pediatrics, 69 Butler St SE, Atlanta 30303 (Dr. Corrigan).

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