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  Vol. 120 No. 3, September 1970 TABLE OF CONTENTS
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Endocrine Manifestations of Neurofibromatosis in Children

Krishna M. Saxena, MD

Am J Dis Child. 1970;120(3):265-271.


Abstract

Endocrine manifestations of neurofibromatosis have been reported in five children, and the literature has been reviewed. Children often show disorders of sexual development and growth, while pheochromocytoma is the commonest endocrine association in adults. Precocious sex development was noted in three children. Two other girls presented with marked retardation of growth. One of them had retarded sex development in association with anorexia nervosa. It has been emphasized that such manifestations may frequently be the presenting features of neurofibromatosis in children.



Author Affiliations

Boston

From the Children's Service, Massachusetts General Hospital, Boston. Dr. Saxena is now with the Department of Pediatrics, University of Minnesota Medical School and Children's Hospital, St. Paul.


Footnotes

Received for publication Feb 10, 1970.

Reprint requests to Children's Hospital, 311 Pleasant Ave, St. Paul 55102 (Dr. Saxena).



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