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Cytomegalovirus in ChildrenPostrenal Transplantation
Richard N. Fine, MD;
Carl M. Grushkin, MD;
Sudhir Anand, MB, BS;
Ellin Lieberman, MD;
Harry T. Wright, Jr, MD
Am J Dis Child. 1970;120(3):197-202.
Abstract
Cytomegalovirus (CMV) was isolated from the urine and/or blood of eight of 21 (38%) pediatric renal allograft recipients. The recovery of CMV was associated with clinical symptomatology in four of the eight patients. Three had cryptogenic fever, and one had anicteric hepatitis. In addition to fever, one patient had evidence of "transplant lung." All of the eight patients had multiple positive urine cultures for as long as 14 months. However, all attempts at virus isolation during these periods were not successful. The fact that cytomegaloviruria was intermittent in all infected patients emphasizes the need for multiple, serial isolation attempts if the true incidence of CMV in renal allograft recipients is to be determined.
Author Affiliations
Los Angeles
From the Department of Pediatrics, University of Southern California School of Medicine, and the divisions of renal disease (Drs. Fine, Grushkin, Anand, and Lieberman) and virology (Dr. Wright), Childrens Hospital of Los Angeles, Los Angeles.
Footnotes
Received for publication April 15, 1970.
Reprint requests to Childrens Hospital of Los Angeles, 4650 Sunset Blvd, Los Angeles 90027 (Dr. Fine).
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