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  Vol. 119 No. 4, April 1970 TABLE OF CONTENTS
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Development and BEI of Low-Birth-Weight Infants Full-Term and Through 18 Months

Evelyn B. Man, PhD; Maurice Adelman, MD; Walter S. Jones, MD; Robert M. Lord, Jr., MD

Am J Dis Child. 1970;119(4):298-307.


Abstract



Serum thyroxine-like iodine compounds (BEI) are essential for normal central nervous system development, but thyroid function tests of full-term and of low-birth-weight infants have not been defined through 18 postnatal months. For 49 full-term infants (normal BEI through five postnatal days 7.2µg to 15.2µg per 100 ml), median and mean BEI from two to six postnatal months were 6.2 ± 0.91 and from 6 to 18 months 5.8µg ± 0.87µg per 100 ml, significantly higher BEI values than for adults. Differences between BEI means of low-birth-weight infants born before and after 34 gestational weeks and of full-term infants were significant at the 0.001 level. Fifteen low-birth-weight infants with BEI determinations until 19 months were examined developmentally; nine, classified normal, appeared to have increasing BEI; six, classified suspect or abnormal, had low or borderline BEI.



Author Affiliations



Providence, RI

From the Thyroid Laboratory, Providence Lying-In Hospital and Institute of Life Sciences, Brown University, Providence, RI.


Footnotes



Received for publication May 15, 1969.

Reprint requests to Thyroid Laboratory, Providence Lying-In Hospital, 50 Maude St, Providence, RI 02908 (Dr. Man).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Editorial: Local Control of the Timing of Thyroid Hormone Action in the Developing Human Brain
Zoeller
J. Clin. Endocrinol. Metab. 2004;89:3114-3116.
FULL TEXT  





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